Job Description

Senior Scientist, Computational Chemistry

PR/156287_1727955021 Posted: 10/03/2024

• US$130000 - US$160000 per annum
• San Francisco, California
• Permanent

Are you ready to join a dynamic team that is revolutionizing drug discovery? We are seeking an innovative Senior Scientist, Computational Chemistry to contribute to cutting-edge small molecule programs targeting GPCRs. If you're passionate about leveraging advanced computational techniques to discover life-changing therapeutics, this is your opportunity to make a meaningful impact.

Company Overview: A biotechnology company based in South San Francisco, CA, with a mission to develop transformative medicines for patients. Utilizing their proprietary platform, the company develops novel drug discovery methods that were previously inaccessible. With a strong emerging pipeline of therapies, they aim to become the industry leader in GPCR-focused drug discovery.

The company values diversity of thought, expertise, and collaboration. As part of this ambitious, multidisciplinary team, you'll work alongside drug hunters, scientists, and business professionals dedicated to addressing the unmet medical needs of patients. This fast-paced, innovative environment is where you can bring your passion, creativity, and expertise to make a difference.

Your role as Senior Scientist, Computational Chemistry:

In this role, you'll be a key contributor to small molecule drug discovery programs by applying advanced in silico methods. Reporting to the Director of Computational Chemistry, you'll work closely with Medicinal Chemistry, Structural Biology, and Research Informatics teams to move from hit identification to lead optimization. You'll also collaborate with external computational experts and use both ligand-based and structure-based design techniques to support GPCR drug discovery efforts.

• Drive computational chemistry strategies using ligand-based (e.g., pharmacophore modeling) and structure-based (e.g., docking, homology models) methods
• Optimize workflows for hit identification, lead optimization, and candidate selection
• Leverage molecular dynamics simulations and free energy perturbation calculations to enhance design efforts
• Collaborate with cross-functional teams in Medicinal Chemistry, Structural Biology, and Research Informatics to develop new hypotheses and drive project success
• Apply modern machine learning techniques and chemical informatics to support drug discovery efforts

Experience and qualifications for the Senior Scientist, Computational Chemistry role:

• Ph.D. in Computational Chemistry, Chemical Informatics, Physical Organic Chemistry, Biophysics, or a related field
• 2-8 years of industrial experience in small molecule drug design
• Expertise in computational drug design methods, including ligand-based and structure-based approaches
• Experience with in silico screening and data analysis of chemical HTS and DEL-library screens is a plus
• Strong collaboration and communication skills, with the ability to make effective presentations and work cross-functionally

Perks and benefits:

• Competitive salary ranging from $130,000 to $160,000, depending on experience and qualifications
• Comprehensive benefits package, stock options, and an annual target bonus
• Opportunities for career growth in a fast-paced, innovative environment
• A collaborative, mission-driven team focused on developing transformative therapeutics for patients

If you're excited to work on the frontlines of drug discovery and development, apply now for immediate consideration.

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