General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.
We are seeking first-rate C omputational Chemists, with previous experience developing PROTACs or related induced-proximity drugs, to help us pioneer this uncharted frontier of drug discovery.
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1] , but there are many other possible perturbation types whose potential remains unrealized.
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2 , 3 , 4 ], and our technology holds the same promise.
We are seeking an experienced Computational Chemist to be a founding member of our Drug Discovery Team. In this position you will work in close conjunction with our Medicinal Chemistry Team in the design and optimization of a completely novel class of therapeutics.
Your responsibilities will include: Spearheading the modeling and informatics initiatives on team projects, strategically applying computational methodologies throughout all stages of the drug discovery process, predicting binding modes and ternary complexes, analyzing crystal structure data, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, and spearheading forays into new disease areas.
High Agency. Initiative, independence, and self-accountability are some of our most valued traits.
Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.
Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.
Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.
Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off.
Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.
Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.
Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.
Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)
Accepted file types: pdf, doc, docx, txt, rtf
Accepted file types: pdf, doc, docx, txt, rtf
LinkedIn Profile *
Personal Website
What is your earliest possible start date? Please enter date in the format of MM/DD/YY. *
What is your preferred start date? Please enter date in the format of MM/DD/YY. *
Are you located in the Bay Area or willing to relocate? * Select...
Do you have (or expect to have) a PhD degree in a relevant field? * Select...
Do you have relevant industry experience in this field? * Select...
Are you legally eligible to work in the U.S.? * Select...
Will you now or in the future require visa sponsorship for employment at General Proximity? * Select...
How did you hear about us? *
What's something you know you need to get better at? *
Anything else we should know about the above answers, or that you'd like to share?
Do you want to opt out of occasional email updates from General Proximity? Select...
#J-18808-Ljbffr...in Baltimore, a Hearst station is seeking a part time Talk Show Host. Live and Local conversation on the issues that matter to the community... ...Television (HTV) owns and/or operates 35 television and two radio stations serving 27 media markets across 39 states reaching over...
...mission-driven team and create relationships that motivate us all every day. Join us today, and experience a career well lived. OPEN INTERVIEWS Friday, November 15th 9am-3pm Where: 413 1st Ave in Vinton Insight to REM Community Services Direct Support...
...PAID on-the-job training with no experience required . The phlebotomist should be a shining example of superior customer service,... ...flexible schedule, including early mornings, late evenings, and weekends. They must be on-time, reliable, good communicators, detail oriented...
...Associate Director of Models and Methods - Computational Chemistry Associate Director of Models and Methods Computational Chemistry In this exciting new role you will manage a team of Data Analysts while crafting computational chemistry structure and innovation...
...Vision, Dental, and Life insurance ~401(k) with employer matching ~ Paid time off ~ Quarterly bonus program ~ Stock sharing ~ Hotel discounts worldwide and more! JOB SUMMARY Our Guest Service Manager serves as a main point of contact for all guest requests....